The biological effect of the endodontic bioactive cements fast set NeoMTA Plus and Pro-Root MTA on osteogenic differentiation of mesenchymal stem cells: A systematic review

ABSTRACT
INTRODUCTION:

Mineral trioxide aggregates (MTA) is the standard material used in endodontic treatment and different dental specialties as pulp capping, repair for root perforation, retrograde filling restoration, apexification and/or revascularization. The aim of this systematic review is to assess the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells.

METHODS:

Two automated databases (Google Scholar and PubMed using English-language literature) were used for this systematic review. The electronic search was done in December 2018 and updated in April 2019.

RESULTS:

Our inquiry uncovered nine studies that met the exclusion and inclusion criteria. These studies investigated the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells. Most of investigations in this review showed the ProRoot-MTA had a greater osteoinductivity and induced the gene expression by different MSCs exposed to it.

CONCLUSION:

Both NeoMTA Plus and ProRoot-MTA had osteogenic activity when used as endodontic repair material.

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