Mineral trioxide aggregates (MTA) is the standard material used in endodontic treatment and different dental specialties as pulp capping, repair for root perforation, retrograde filling restoration, apexification and/or revascularization. The aim of this systematic review is to assess the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells.
Two automated databases (Google Scholar and PubMed using English-language literature) were used for this systematic review. The electronic search was done in December 2018 and updated in April 2019.
Our inquiry uncovered nine studies that met the exclusion and inclusion criteria. These studies investigated the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells. Most of investigations in this review showed the ProRoot-MTA had a greater osteoinductivity and induced the gene expression by different MSCs exposed to it.
Both NeoMTA Plus and ProRoot-MTA had osteogenic activity when used as endodontic repair material.