Tag: Biocompatibility/ Cytotoxicity

In vitro biocompatibility and oxidative stress profiles of different hydraulic calcium silicate cements

ABSTRACT INTRODUCTION: MTA Plus is a new calcium silicate cement with unknown cytotoxicity characteristics. The objectives of this study were to examine the effect of MTA Plus on the viability, apoptosis/necrosis profile, and oxidative stress levels of rat odontoblastlike cells. METHODS: MDPC-23 cells were exposed to gray and white MTA Plus (GMTAP, WMTAP), gray and […]

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X-ray diffraction analysis of MTA-Plus, MTA-Angelus and DiaRoot BioAggregate

ABSTRACT INTRODUCTION: The purpose of this study was to investigate and compare the crystalline structures of recently released MTA Plus (MTAP), MTA Angelus (MTA-A), DiaRoot BioAggregate (BA) by X-ray diffraction (XRD) analysis. METHODS: Phase analysis was carried out on powder and set forms of tested materials. The powder specimens placed into sample holders that were […]

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Biocompatibility and bioactivity of calcium silicate based endodontic sealers in human dental pulp cells

ABSTRACT INTRODUCTION: Mineral Trioxide Aggregate (MTA) is a calcium silicate-based material. New sealers have been developed based on calcium silicate as MTA Fillapex and MTA Plus. The aim of this study was to evaluate biocompatibility and bioactivity of these two calcium silicate-based sealers in culture of humandental pulp cells (hDPCs). METHODS: The cells were isolated […]

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Human dental pulp cells response to mineral trioxide aggregate (MTA) and MTA Plus: cytotoxicity and gene expression analysis

ABSTRACTINTRODUCTION: The aim of this study is to investigate the cytotoxicity, osteogenic bioactivity and mRNA expression of osteogenic markers of bone morphogenetic protein 2 (BMP-2), osteocalcin (OC) and alkaline phosphatase (ALP) induced by the extracts of set MTA Plus (MTA P) (Avalon Biomed Inc. Bradenton, FL, USA) in comparison with MTA (Angelus, Londrina, PR, Brazil) […]

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Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide

ABSTRACT INTRODUCTION: The aim of this study is to evaluate the biocompatibility and mineralized nodule formation of an experimental tricalcium silicate cement with tantalum oxide (TSC/T2aO5) as radiopacifier, Neo MTA Plus (Avalon Biomed Inc., Bradenton, FL, USA) and MTA (Angelus, Londrina, PR, Brazil) on human osteoblast-like cells (Saos-2). METHODS: Biocompatibility was evaluated by 3-(4,5-dimethyl-thiazoyl)-2,5-diphenyl-tetrazolium bromide […]

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Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells.

ABSTRACT INTRODUCTION: The aim of the present study was to evaluate the in vitro cytotoxicity of MTA Repair HP, NeoMTA Plus, and Biodentine, newbioactive materials used for dental pulp capping, on human dental pulp stem cells (hDPSCs). METHODS: Biological testing was carried out in vitro on hDPSCs. Cell viability and cell migration assays were performed […]

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Cell Viability and Tissue Reaction of NeoMTA Plus: An In Vitro and In Vivo Study

Abstract: The aim of this study was to evaluate the cell viability and tissue reaction of NeoMTA Plus (NMP; Avalon Biomed Inc, Houston, TX) compared with mineral trioxide aggregate (MTA; Angelus, Londrina, PR, Brazil) and Biodentine (BD; Septodont, Saint-Maur-de-Fossés, France). METHODOLOGY:Fibroblasts (3T3) were plated and exposed to 1% extract from the test material before and […]

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Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells

Abstract: The aim of the present study was to evaluate the in vitro cytotoxicity of MTA Repair HP, NeoMTA Plus, and Biodentine, newbioactive materials used for dental pulp capping, on human dental pulp stem cells (hDPSCs). METHODOLOGY: Biological testing was carried out in vitro on hDPSCs. Cell viability and cell migration assays were performed using […]

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Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide.

Abstract: Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide. International Endodontic Journal. AIM: To evaluate the biocompatibility and mineral-ized nodule formation of an experimental tricalcium silicate cement with tantalum oxide (TSC/T2aO5) as radiopacifier, Neo MTA Plus (Avalon Biomed Inc., Bradenton, FL, USA) and MTA (Angelus, […]

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Human dental pulp cells response to mineral trioxide aggregate (MTA) and MTA Plus: cytotoxicity and gene expression analysis.

ABSTRACT AIM: To investigate the cytotoxicity, osteogenic bioactivity and mRNA expression of osteogenic markers of bone morphogenetic protein 2 (BMP-2), osteocalcin (OC) and alkaline phosphatase (ALP) induced by the extracts of set MTA Plus (MTA P) (Avalon Biomed Inc. Bradenton, FL, USA) in comparison with MTA (Angelus, Londrina, PR, Brazil) on human dental pulp cells […]

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