Scientific Articles
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Bone tissue reaction, setting time, solubility, and pH of root repair materials
August 11, 2020PURPOSE This study aims to compare the bone tissue reaction, setting time, solubility, and pH of NeoMTA Plus, Biodentine (BD), and MTA Angelus (MTA-A). METHODS Initial and final setting times (n = 7) and solubility up to 7 days (n = 11) were evaluated in accordance with ASTM C266–15 and ANSI/ADA Specification No. 57, respectively. pH (n = 10) was measured […]...Read more
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Comparison of the sealing ability of apical plug materials in simulated open apices: An in vitro study
July 29, 2020PURPOSE The aim of this study was to evaluate the microleakage of apical plugs made of four different materials in simulated immature teeth. METHODS Ninety extracted single-rooted teeth were selected and randomly divided into six groups according to the materials used: NeoMTA, EndoSequence Bioceramic Root Repair Material Fast Set Putty (BC RRMFS), Biodentine, Endo Repair, […]...Read more
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Shear Bond Comparison between 4 Bioceramic Materials and Dual-cure Composite Resin
November 22, 2019ABSTRACT INTRODUCTION: Bioceramic materials have shown biologic and physical properties favorable for regenerative treatment. A key to treatment success is an adequate restoration to prevent microleakage; however, research is limited regarding the bond strength between restorative and bioceramic materials used in regenerative procedures. This study compared the bond strength between 4 bioceramic materials and a […]...Read more
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Physical and chemical properties of new-generation endodontic materials
November 22, 2019ABSTRACT INTRODUCTION: Mineral trioxide aggregate (MTA), white and gray, has many uses in endodontic therapy but is limited by its difficult handling characteristics. This study compared the physical and chemical properties of white MTA (WMTA) with three experimental root-end filling materials: Capasio (Primus Consulting, Bradenton, FL), Ceramicrete-D (Tulsa Dental Specialties/Argonne National Laboratory, Argonne, IL), and […]...Read more
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Biocompatibility and osteogenic potential of new generation endodontic materials established by using primary osteoblasts
November 22, 2019ABSTRACT INTRODUCTION: Generex A and Generex B (calcium silicate based), Capasio (calcium-phospho-alumino silicate based) along with Ceramicrete-D (magnesium phosphate based) are being introduced as a new generation of endodontic materials with the potential to facilitate bone healing. The aim of this study was to evaluate the biocompatibility and osteogenic potential of these new materials by […]...Read more
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Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate
November 22, 2019ABSTRACT Fluoride-releasing restorative materials are available for remineralization of enamel and root caries. However, remineralization of dentin is more difficult than remineralization of enamel due to the paucity of apatite seed crystallites along the lesion surface for heterogeneous crystal growth. Extracellular matrix proteins play critical roles in controlling apatite nucleation/growth in collagenous tissues. This study […]...Read more
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Effects of calcium silicate-based materials on the flexural properties of dentin
November 22, 2019ABSTRACT INTRODUCTION: Prolonged exposure of root dentin to calcium hydroxide alters the fracture resistance of dentin. Calcium silicate-based materials (CSMs) used in endodontics release calcium hydroxide on setting. This study examined whether prolonged contact of dentin with CSMs adversely affects its mechanical properties. METHODS: Dentin beams prepared from extracted human molars (7 × 3 × […]...Read more
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Effects of an experimental calcium aluminosilicate cement on the viability of murine odontoblast-like cells
November 22, 2019ABSTRACT INTRODUCTION: Quick-setting calcium aluminosilicate cement with improved washout resistance is a potential substitute for calcium silicate cements in endodontics. This study examined the effect of an experimental calcium aluminosilicate cement (Quick-Set; Primus Consulting, Bradenton, FL) on the viability of odontoblast-like cells. METHODS: The biocompatibility of Quick-Set and white ProRoot MTA (WMTA; Dentsply Tulsa Dental […]...Read more
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Mineral trioxide aggregate with anti-washout gel – properties and microstructure
November 22, 2019ABSTRACT INTRODUCTION: One of the problems encountered clinically when using mineral trioxide aggregate (MTA) as a root-end filling material is washout immediately after placement. A novel MTA is supplied with an anti-washout gel that replaces the mixing water. The aim of this research was to characterize and assess the properties of a novel MTA mixed […]...Read more
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Retreatability of 2 mineral trioxide aggregate-based root canal sealers: a conebeam computed tomography analysis
November 22, 2019ABSTRACT INTRODUCTION: The retreatability of recent calcium silicate or mineral trioxide aggregate (MTA) sealers has not yet been assessed. The aim of this study was to evaluate the removal of 2 MTA-based sealers (MTA Fillapex [Angelus Soluções Odontológicas, Londrina, PR, Brazil] and MTA Plus [Prevest-Denpro, Jammu City, India]) using a rotary retreatment system, considering an […]...Read more
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The setting characteristics of MTA Plus in different environmental conditions
November 22, 2019ABSTRACT INTRODUCTION: Characterization and assessment of the hydration reaction of mineral trioxide aggregate (MTA) Plus exposed to different environmental conditions. METHODS: The specific surface area, surface morphology and characterization of un-hydrated MTA Plus (Avalon Biomed Inc. Bradenton, FL, USA) were investigated. The specific surface area was compared with that of ProRoot MTA (Dentsply International, Tulsa […]...Read more
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In vitro osteogenic/dentinogenic potential of an experimental calcium aluminosilicate cement
November 22, 2019ABSTRACT INTRODUCTION: Calcium aluminosilicate cements are fast-setting, acid-resistant, bioactive cements that may be used as root-repair materials. This study examined the osteogenic/dentinogenic potential of an experimental calcium aluminosilicate cement (Quick-Set) by using a murine odontoblast-like cell model. METHODS: Quick-Set and white ProRoot MTA (WMTA) were mixed with the proprietary gel or deionized water, allowed to […]...Read more
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In vitro biocompatibility and oxidative stress profiles of different hydraulic calcium silicate cements
November 22, 2019ABSTRACT INTRODUCTION: MTA Plus is a new calcium silicate cement with unknown cytotoxicity characteristics. The objectives of this study were to examine the effect of MTA Plus on the viability, apoptosis/necrosis profile, and oxidative stress levels of rat odontoblastlike cells. METHODS: MDPC-23 cells were exposed to gray and white MTA Plus (GMTAP, WMTAP), gray and […]...Read more
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X-ray diffraction analysis of MTA-Plus, MTA-Angelus and DiaRoot BioAggregate
November 22, 2019ABSTRACT INTRODUCTION: The purpose of this study was to investigate and compare the crystalline structures of recently released MTA Plus (MTAP), MTA Angelus (MTA-A), DiaRoot BioAggregate (BA) by X-ray diffraction (XRD) analysis. METHODS: Phase analysis was carried out on powder and set forms of tested materials. The powder specimens placed into sample holders that were […]...Read more
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Push-out bond strength of MTA with antiwashout gel or resins
November 22, 2019ABSTRACT INTRODUCTION: This study’s aim was to make an assessment of the push-out bond strength of four MTA-based formulations for use as root-end filling materials. METHODS: MTA Plus mixed with (i) water (‘MTA-W’); (ii) a proprietary water-based antiwashout gel (‘MTA-AW’); (iii) Superbond C&B chemically curing resin (‘MTA-Chem’); and (iv) Heliobond light-curing resin (‘MTA-Light’) was tested. […]...Read more
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Evaluation of compressive strength of hydraulic silicate-based root-end filling materials
November 22, 2019ABSTRACT INTRODUCTION: Hydraulic silicate cements such as mineral trioxide aggregate (MTA) have many clinical advantages. Newer hydraulic silicate materials have been developed that improve on the limitations of mineral trioxide aggregate such as the long setting time and difficult handling characteristics. The purpose of this study was to examine the effect of saline and fetal […]...Read more
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Ion release, porosity, solubility, and bioactivity of MTA Plus tricalcium silicate
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study was to evaluate MTA Plus (Prevest Denpro Limited, Jammu, India, for Avalon Biomed Inc) material’s properties, namely calcium release, the pH change, solubility, water sorption, porosity, surface morphology, and apatiteforming ability after immersion in simulated body fluid. METHODS: Two tricalcium silicate powders (MTA Plus and ProRoot MTA; Dentsply […]...Read more
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Marginal Adaptation Evaluation of Biodentine and MTA Plus in “Open Sandwich” Class II Restorations
November 22, 2019ABSTRACT INTRODUCTION: This study aimed at evaluation of two different commercially available calcium silicate materials (Biodentine and mineral trioxide aggregate [MTA] Plus) used as dentin substitute. METHODS: Sixty Class II cavities were prepared in extracted mandibular third molars, with margins extending 1 mm below the cementum-enamel junction. The samples were divided into three groups on […]...Read more
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The effect of root dentin conditioning protocols on the push-out bond strength of three calcium silicate sealers
November 22, 2019ABSTRACT INTRODUCTION: The objective was to compare the effects of irrigation protocols on the push-out bond strength of calcium silicate materials at two different time periods (7-days and 3-months). METHODS: Root canals (n=300) were irrigated with one of the following (n=60): group 1 (3% NaOCl–17% EDTA); group 2 (17% EDTA–3% NaOCl); group 3 (1:1 mixture […]...Read more
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Biocompatibility and bioactivity of calcium silicate based endodontic sealers in human dental pulp cells
November 22, 2019ABSTRACT INTRODUCTION: Mineral Trioxide Aggregate (MTA) is a calcium silicate-based material. New sealers have been developed based on calcium silicate as MTA Fillapex and MTA Plus. The aim of this study was to evaluate biocompatibility and bioactivity of these two calcium silicate-based sealers in culture of humandental pulp cells (hDPCs). METHODS: The cells were isolated […]...Read more
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Comparative Analysis of Calcium Silicate-based Root Filling Materials Using an Open Apex Model
November 22, 2019ABSTRACT INTRODUCTION: Many new calcium silicate-based root filling materials have emerged in the market; however, their performance in the orthograde obturation of an open apex has not been evaluated. The purpose of this study was to compare the marginal adaptation of ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK), NeoMTA Plus (Avalon Biomed Inc, Bradenton, FL), […]...Read more
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Dentinal Tubule Penetration of Tricalcium Silicate Sealers
November 22, 2019ABSTRACT INTRODUCTION: The treatments for which mineral trioxide aggregate (MTA)-based materials can be used in dentistry are expanding. Smaller particle size and easier handling properties have allowed the advent of tricalcium silicate sealers including EndoSequence BC Sealer (Brasseler USA, Savannah, GA), QuickSet2 (Avalon Biomed, Bradenton, FL), NeoMTA Plus (Avalon Biomed), and MTA Fillapex (Angelus, Londrina, […]...Read more
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Evaluation of cytotoxicity and gelatinases activity in 3T3 fibroblasts cell by root repair materials
November 22, 2019ABSTRACT The aim of this study was to investigate the effects of calcium silicate-based products on cytotoxicity in the 3T3 fibroblast and gelatinolytic activity of matrix metalloproteinases (MMPs). 3T3 fibroblasts were incubated directly with Ortho Mineral trioxide aggregate (MTA), BioAggregate, Biodentine, MTA Plus, MTA Angelus and MTA Cerkamed for 24 hours and seven days. The […]...Read more
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Effect of root canal irrigating solutions on the compressive strength of tricalcium silicate cements
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study was to evaluate the effect of root canal irrigants on the compressive strength of hydraulic tricalcium silicate cements. METHODS: Specimens (n = 60) of tricalcium silicate materials-Group 1: White ProRoot mineral trioxide aggregate (MTA), Group 2: NeoMTA Plus, Group 3: White MTA Angelus, and Group 4: Biodentine were […]...Read more
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Human dental pulp cells response to mineral trioxide aggregate (MTA) and MTA Plus: cytotoxicity and gene expression analysis
November 22, 2019ABSTRACTINTRODUCTION: The aim of this study is to investigate the cytotoxicity, osteogenic bioactivity and mRNA expression of osteogenic markers of bone morphogenetic protein 2 (BMP-2), osteocalcin (OC) and alkaline phosphatase (ALP) induced by the extracts of set MTA Plus (MTA P) (Avalon Biomed Inc. Bradenton, FL, USA) in comparison with MTA (Angelus, Londrina, PR, Brazil) […]...Read more
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Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells
November 22, 2019ABSTRACT INTRODUCTION: Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells. The aim of this study was to evaluate the biological effects in vitro of MTAAngelus (MTA-Ang; Angelus, Londrina, PR, Brazil), MTA Repair HP (MTA-HP; Angelus) and NeoMTA Plus (NeoMTA-P; […]...Read more
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Osteoinductive potential and bone-bonding ability of ProRoot MTA, MTA Plus and Biodentine in rabbit intramedullary model: Microchemical characterization and histological analysis
November 22, 2019ABSTRACT INTRODUCTION: The objective was to study the in vivo osteoinductive potential, bone-bonding ability (bioactivity) and bone biomineralization of current hydraulic calcium silicate cements used as graft materials and placed in contact with medullary bone. METHODS: ProRoot MTA, MTA Plus and Biodentine were used to fill surgical bone defects (2-mm diameter through the entire cortical […]...Read more
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Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study is to evaluate the biocompatibility and mineralized nodule formation of an experimental tricalcium silicate cement with tantalum oxide (TSC/T2aO5) as radiopacifier, Neo MTA Plus (Avalon Biomed Inc., Bradenton, FL, USA) and MTA (Angelus, Londrina, PR, Brazil) on human osteoblast-like cells (Saos-2). METHODS: Biocompatibility was evaluated by 3-(4,5-dimethyl-thiazoyl)-2,5-diphenyl-tetrazolium bromide […]...Read more
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Effect of Sodium Hypochlorite on Push-out Bond Strength of Four Calcium Silicate-based Endodontic Materials when used for repairing Perforations on Human Dentin: An in vitro Evaluation
November 22, 2019ABSTRACT INTRODUCTION: This study aimed to evaluate the push-out bond strength of NeoMTA Plus (NMTA), EndoSequence root repair material fast set putty (ERRMF), biodentine (BD), and ProRoot white mineral trioxide aggregate (PMTA) when used as perforation repair materials after exposure to 2.5% sodium hypochlorite (NaOCl) during the early setting phase. METHODS: Horizontal midroot sections were […]...Read more
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Properties of NeoMTA Plus and MTA Plus cements for endodontics
November 22, 2019ABSTRACT INTRODUCTION: To test a novel calcium silicate cement mixed with a water-based gel (NeoMTA Plus) with regard to chemical-physical properties and apatite-forming ability. METHODS: NeoMTA Plus (Avalon Biomed Inc. Bradenton, FL, USA; lot. 2014090301) and a commercial MTA-based material with similar properties (MTA Plus, Prevest Denpro Limited, Jammu, India; lot. 41001) were tested for […]...Read more
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Stereomicroscopic Dye Leakage Measurement of Six Different Root Canal Sealers
November 22, 2019ABSTRACT INTRODUCTION: The present study was done for evaluating microleakage in different root canal sealers. METHODS: Sixty extracted human single rooted teeeth were used in this in-vitro study. Sealers tested for microleakage in this study were zinc oxide eugenol based sealer, Sealapex, AH Plus, MTA Plus, EndoRez, Endosequence BC. All the specimens were examined under […]...Read more
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Pulp Vitality in Pediatric Patients
November 22, 2019ABSTRACT INTRODUCTION: Vital pulp therapy is practiced daily in dentistry. We routinely arrest or remove carious lesions in our offices using a variety of treatments. There is some debate, though, in the fields of pediatric dentistry and endodontics about therapy for vital permanent teeth with deep carious lesions. There are several clinical techniques for treating […]...Read more
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Cost Estimates for Bioactive Cement Pulpotomies and Crowns in Primary Molars
November 22, 2019ABSTRACT INTRODUCTION: Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells. METHODS: Thirty extracted primary molars were divided into five groups, each having two sets of three teeth (one first molar and two second molars). Pulpotomy and restorative options were […]...Read more
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Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells.
November 22, 2019ABSTRACT INTRODUCTION: The aim of the present study was to evaluate the in vitro cytotoxicity of MTA Repair HP, NeoMTA Plus, and Biodentine, newbioactive materials used for dental pulp capping, on human dental pulp stem cells (hDPSCs). METHODS: Biological testing was carried out in vitro on hDPSCs. Cell viability and cell migration assays were performed […]...Read more
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Acidic and alkaline chemicals’ influence on a tricalcium silicate-based dental biomaterial
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study was to determine the effect of five common chemical agents used in root canal preparation (sodium hypochlorite/NaOCl, ethylene diaminetetraacetic acid/EDTA, mixture of sodium hypochlorite and etidronic acid/NaOCl + EA, mixture of EDTA and Chlorhexidine/QMix, or saline) on a commercial tricalcium silicate (MTA Plus). METHODS: Samples were analyzed using […]...Read more
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Biocompatibility of mineral trioxide aggregate flow and biodentine
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study is to evaluate the influence of powder‐to‐gel ratio (0.19 g powder to 50 μL of gel, thick MTA Flow, and 0.06 g powder to 50 μL of gel, fluid MTA Flow) on biocompatibility of MTA Flow (Ultradent Products Inc., South Jordan, UT, USA, lot: 2015122901) and compare it […]...Read more
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Higher hydration performance and bioactive response of the new endodontic bioactive cement MTA HP repair compared with ProRoot MTA white and NeoMTA plus
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study was to characterize the hydration performance and the bioactive response of the new bioactive endodontic cement MTA HP repair (HP), comparing its physicochemical parameters with those of ProRoot MTA White (Pro) and NeoMTA Plus (Neo). Un‐hydrated precursor materials were characterized by X‐ray fluorescence, laser diffraction, N2 physisorption and […]...Read more
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Chemistry and Bioactivity of NeoMTA Plus™ versus MTA Angelus® Root Repair
November 22, 2019ABSTRACT INTRODUCTION: The aim of this study is to analyze the chemistry and bioactivity of NeoMTA Plus in comparison with the conventional root repair materials. METHODS: Unhydrated and hydrated (initial and final sets) materials were analyzed by Fourier transform infrared(FTIR) spectroscopy and X-ray diffraction (XRD). For bioactivity study, small holes of dentin discs were filled […]...Read more
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Color Stability of NeoMTA Plus and MTA Plus when mixed with Anti-washout Gel or Distilled Water
November 22, 2019ABSTRACT INTRODUCTION: This study aims to evaluate the effect of the special anti-washout gel mixing agent on the color stability of mineral trioxide aggregate (MTA) Plus and NeoMTA Plus in contact with distilled water, ethylenediaminetetraacetic acid (EDTA) and sodium hypochlorite (NaOCl). METHODS: One set of three specimens was mixed using the antiwashout gel and the […]...Read more
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The biological effect of the endodontic bioactive cements fast set NeoMTA Plus and Pro-Root MTA on osteogenic differentiation of mesenchymal stem cells: A systematic review
November 22, 2019ABSTRACT INTRODUCTION: Mineral trioxide aggregates (MTA) is the standard material used in endodontic treatment and different dental specialties as pulp capping, repair for root perforation, retrograde filling restoration, apexification and/or revascularization. The aim of this systematic review is to assess the osteogenic activity of NeoMTA Plus in compared with ProRoot-MTA using mesenchymal stem cells. METHODS: […]...Read more
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Evaluation of changes in ion release and biological properties of NeoMTA-Plus and Endocem-MTA exposed to an acidic enviornment
November 22, 2019ABSTRACT INTRODUCTION: The purpose of this study is to analyze in vitro changes in ion release and biological properties of Endocem-MTA (Maruchi, Wonju, Korea) and NeoMTA-Plus (Avalon Biomed Inc, Bradenton, FL, USA) exposed to acidic or neutral environment on human dental periodontal ligament stem cells (hPDLSCs). METHODS: Cell viability and wound healing assays were performed […]...Read more
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Staining Potential of Neo MTA Plus, MTA Plus, and Biodentine Used for Pulpotomy Procedures
November 5, 2019ABSTRACT INTRODUCTION: Mineral trioxide aggregate (MTA) used for pulpotomy procedures in immature permanent teeth can reduce treatment to 1 session as opposed to classic calcium hydroxide therapy, which necessitates multiple appointments. The main disadvantage of MTA use is crown discoloration after treatment. The aim of this study was to characterize 3 materials that are used […]...Read more
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Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues.
November 4, 2019Abstract: Over 2500 articles and 200 reviews have been published on the bioactive tri/dicalcium silicate dental materials. The indications have expanded since their introduction in the 1990s from endodontic restorative and pulpal treatments to endodontic sealing and obturation. Bioactive ceramics, based on tri/dicalcium silicate cements, are now an indispensable part of the contemporary dental armamentarium […]...Read more
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A Randomized Clinical Trial of NeoMTA Plus in Primary Molar Pulpotomies.
October 31, 2019ABSTRACT The purpose of this study was to compare the success of pulpotomies in primary molars using a new type of mineral trioxide aggregate (MTA; NeoMTA Plus) with a conventional MTA (ProRoot MTA) as a pulpotomy medicament in primary molars. METHODOLOGY: Eighty primary teeth in 28 patients were divided randomly, with 40 teeth in a […]...Read more
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Mineral trioxide aggregate: present and future developments
December 27, 2018Portland cement is used in the building industry to make concrete. It is hydraulic and thus it develops its properties well in the presence of moisture. The oral environment is inherently wet, however, all dental materials need a dry field for optimal performance. A mixture of Portland cement and busmuth oxide was developed and marketed […]...Read more
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Histologic Assessment of Quick-Set and Mineral Trioxide Aggregate Pulpotomies in a Canine Model
December 27, 2018Introduction: Quick-Set (Primus Consulting, Bradenton, FL) is a calcium aluminosilicate cement that is a potential alternative to mineral trioxide aggregate (MTA) with greater acid resistance and faster setting. The purpose of this study was to compare the effects of Quick-Set and MTA on pulpal tissues in response to pulpotomy procedures. Methods: The pulp chambers of […]...Read more
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Effect of Sodium Hypochlorite on Push-out Bond Strength of Four Calcium Silicate-based Endodontic Materials when used for repairing Perforations on Human Dentin: An in vitro Evaluation
December 27, 2018Abstract: This study aimed to evaluate the push-out bond strength of NeoMTA Plus (NMTA), EndoSequence root repair material fast set putty (ERRMF), biodentine (BD), and ProRoot white mineral trioxide aggregate (PMTA) when used as perforation repair materials after exposure to 2.5% sodium hypochlorite (NaOCl) during the early setting phase. METHODOLOGY: Horizontal midroot sections were prepared […]...Read more
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Histology of NeoMTA Plus and Quick-Set2 in Contact with Pulp and Periradicular Tissues in a Canine Model.
September 1, 2018ABSTRACT: The purpose of this study was to compare the healing of pupal and periapical tissues in dogs after exposure to NeoMTA Plus and Quick-Set2 after pulpotomy and root-end surgery procedures. METHODOLOGY: Seventy-two teeth (36 for each procedure) in 6 beagle dogs received pulpotomy or root-end surgery using either NeoMTA Plus or Quick-Set2. The dogs […]...Read more
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Cell Viability and Tissue Reaction of NeoMTA Plus: An In Vitro and In Vivo Study
July 27, 2018Abstract: The aim of this study was to evaluate the cell viability and tissue reaction of NeoMTA Plus (NMP; Avalon Biomed Inc, Houston, TX) compared with mineral trioxide aggregate (MTA; Angelus, Londrina, PR, Brazil) and Biodentine (BD; Septodont, Saint-Maur-de-Fossés, France). METHODOLOGY:Fibroblasts (3T3) were plated and exposed to 1% extract from the test material before and […]...Read more
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Bioactive endodontic materials for everyday use: a review
July 1, 2018Abstract: Bioceramic materials are at the forefront of modern dentistry. Bioactive bioceramic endodontic materials promote pulpal and periapical tissue healing and are easy to use. Dentists can choose among many endodontic materials, depending on their needs. This article highlights the major differences among commercially available bioactive tricalcium silicate bioceramics, commonly known as mineral trioxide aggregate […]...Read more
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Fracture Resistance of Teeth with Simulated Perforating Internal Resorption Cavities Repaired with Different Calcium Silicate-based Cements and Backfilling Materials
May 1, 2018Abstract: This study assessed the fracture resistance (FR) of teeth with simulated perforating internal resorption cavities repaired with different calcium silicate-based cements (CSCs) and backfilling materials. METHODOLOGY: Ninety-six mandibular premolar teeth were used. Twelve of the teeth were assigned as negative control group. Remaining roots were instrumented with rotary files, and standardized internal resorption cavities […]...Read more
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Increasing Use of Bioceramics in Endodontics: A Narrative Review
May 1, 2018Abstract: Successful outcomes of root canal treatment, in addition to a multitude of factors, also depends on the prevention of reinfection of the root canal space. The ultimate goal of root canal treatment is prevention or healing of apical periodontitis. The use of biologically active materials to seal root canal systems has been extensively proposed […]...Read more
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Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells
January 1, 2018Abstract: The aim of the present study was to evaluate the in vitro cytotoxicity of MTA Repair HP, NeoMTA Plus, and Biodentine, newbioactive materials used for dental pulp capping, on human dental pulp stem cells (hDPSCs). METHODOLOGY: Biological testing was carried out in vitro on hDPSCs. Cell viability and cell migration assays were performed using […]...Read more
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Cost Estimates for Bioactive Cement Pulpotomies and Crowns in Primary Molars
January 1, 2018Abstract: Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells. METHODOLOGY: Thirty extracted primary molars were divided into five groups, each having two sets of three teeth (one first molar and two second molars). Pulpotomy and restorative options were randomly […]...Read more
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Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells.
December 1, 2017Abstract: Comparative analysis of the biological effects of the endodontic bioactive cements MTA-Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells. AIM: To evaluate the biological effects in vitro of MTAAngelus (MTA-Ang; Angelus, Londrina, PR, Brazil), MTA Repair HP (MTA-HP; Angelus) and NeoMTA Plus (NeoMTA-P; Avalon Biomed Inc, Bradenton, FL, USA) […]...Read more
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Pulp Vitality in Pediatric Patients
July 1, 2017Abstract: Vital pulp therapy is practiced daily in dentistry. We routinely arrest or remove carious lesions in our offices using a variety of treatments. There is some debate, though, in the fields of pediatric dentistry and endodontics about therapy for vital permanent teeth with deep carious lesions. There are several clinical techniques for treating vital […]...Read more
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Stereomicroscopic Dye Leakage Measurement of Six Different Root Canal Sealers
June 1, 2017Abstract: The present study was done for evaluating microleakage in different root canal sealers. METHODOLOGY: Sixty extracted human single rooted teeeth were used in this in-vitro study. Sealers tested for microleakage in this study were zinc oxide eugenol based sealer, Sealapex, AH Plus, MTA Plus, EndoRez, Endosequence BC. All the specimens were examined under stereomicroscope […]...Read more
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Properties of NeoMTA Plus and MTA Plus cements for endodontics
June 1, 2017Abstract: To test a novel calcium silicate cement mixed with a water-based gel (NeoMTA Plus) with regard to chemical-physical properties and apatite-forming ability. METHODOLOGY: NeoMTA Plus (Avalon Biomed Inc. Bradenton, FL, USA; lot. 2014090301) and a commercial MTA-based material with similar properties (MTA Plus, Prevest Denpro Limited, Jammu, India; lot. 41001) were tested for ion-releasing […]...Read more
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Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide.
April 1, 2017Abstract: Biocompatibility and mineralized nodule formation of Neo MTA Plus and an experimental tricalcium silicate cement containing tantalum oxide. International Endodontic Journal. AIM: To evaluate the biocompatibility and mineral-ized nodule formation of an experimental tricalcium silicate cement with tantalum oxide (TSC/T2aO5) as radiopacifier, Neo MTA Plus (Avalon Biomed Inc., Bradenton, FL, USA) and MTA (Angelus, […]...Read more
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Osteoinductive potential and bone-bonding ability of ProRoot MTA, MTA Plus and Biodentine in rabbit intramedullary model: Microchemical characterization and histological analysis.
February 1, 2017ABSTRACT OBJECTIVE: To study the in vivo osteoinductive potential, bone-bonding ability (bioactivity) and bone biomineralization of current hydraulic calcium silicate cements used as graft materials and placed in contact with medullary bone. METHODS: ProRoot MTA, MTA Plus and Biodentine were used to fill surgical bone defects (2-mm diameter through the entire cortical thickness to reach […]...Read more
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Comparative evaluation of push-out bond strength of NeoMTA Plus with Biodentine and white ProRoot MTA.
September 1, 2016ABSTRACT OBJECTIVE: The aim of this in vitro study was to evaluate the bond strength of a new calcium silicate cement, Neo MTA Plus (Avalon Biomed Inc. Bradenton, FL, U.S.A) by comparing ProRoot MTA and Biodentine. MATERIAL AND METHODS: Sixty dentin slices were instrumented to achieve a diameter of 1.3 mm. Group 1: white ProRoot […]...Read more
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Human dental pulp cells response to mineral trioxide aggregate (MTA) and MTA Plus: cytotoxicity and gene expression analysis.
August 1, 2016ABSTRACT AIM: To investigate the cytotoxicity, osteogenic bioactivity and mRNA expression of osteogenic markers of bone morphogenetic protein 2 (BMP-2), osteocalcin (OC) and alkaline phosphatase (ALP) induced by the extracts of set MTA Plus (MTA P) (Avalon Biomed Inc. Bradenton, FL, USA) in comparison with MTA (Angelus, Londrina, PR, Brazil) on human dental pulp cells […]...Read more
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Effect of root canal irrigating solutions on the compressive strength of tricalcium silicate cements.
July 1, 2016Abstract OBJECTIVES: The aim of this study was to evaluate the effect of root canal irrigants on the compressive strength of hydraulic tricalcium silicate cements. MATERIALS AND METHODS: Specimens (n = 60) of tricalcium silicate materials-Group 1: White ProRoot mineral trioxide aggregate (MTA), Group 2: NeoMTA Plus, Group 3: White MTA Angelus, and Group 4: Biodentine were exposed to […]...Read more
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Evaluation of cytotoxicity and gelatinases activity in 3T3 fibroblasts cell by root repair materials
June 1, 2016Abstract The aim of this study was to investigate the effects of calcium silicate-based products on cytotoxicity in the 3T3 fibroblast and gelatinolytic activity of matrix metalloproteinases (MMPs). 3T3 fibroblasts were incubated directly with Ortho Mineral trioxide aggregate (MTA), BioAggregate, Biodentine, MTA Plus, MTA Angelus and MTA Cerkamed for 24 hours and seven days. The […]...Read more
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Dentinal Tubule Penetration of Tricalcium Silicate Sealers.
April 1, 2016Abstract INTRODUCTION: The treatments for which mineral trioxide aggregate (MTA)-based materials can be used in dentistry are expanding. Smaller particle size and easier handling properties have allowed the advent of tricalcium silicate sealers including EndoSequence BC Sealer (Brasseler USA, Savannah, GA), QuickSet2 (Avalon Biomed, Bradenton, FL), NeoMTA Plus (Avalon Biomed), and MTA Fillapex (Angelus, Londrina, Brazil). […]...Read more
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Comparative Analysis of Calcium Silicate-based Root Filling Materials Using an Open Apex Model.
April 1, 2016Abstract INTRODUCTION: Many new calcium silicate-based root filling materials have emerged in the market; however, their performance in the orthograde obturation of an open apex has not been evaluated. The purpose of this study was to compare the marginal adaptation of ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK), NeoMTA Plus (Avalon Biomed Inc, Bradenton, FL), and […]...Read more
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Osteogenic and Angiogenic Response to Calcium Silicate–based Endodontic Sealers
January 1, 2016Abstract Introduction:Calcium silicate–based endodontic sealers are reported to favor the regeneration of periradicular tissues, a process requiring concerted osteogenicand angiogenic events. This study compared 4 calciumsilicate–based sealers for the effects of their extracts on osteogenic and angiogenic cell behavior. Methods: Extracts from ProRoot MTA (Dentsply Tulsa Dental, Tulsa, OK), MTA Plus (Prevest Denpro Limited, JammuCity, […]...Read more
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Biocompatibility and bioactivity of calcium silicate based endodontic sealers in human dental pulp cells.
October 1, 2015ABSTRACT Mineral Trioxide Aggregate (MTA) is a calcium silicate-based material. New sealers have been developed based on calcium silicate as MTA Fillapex and MTA Plus. OBJECTIVE: The aim of this study was to evaluate biocompatibility and bioactivity of these two calcium silicate-based sealers in culture of humandental pulp cells (hDPCs). MATERIAL AND METHODS: The cells […]...Read more
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The effect of root dentin conditioning protocols on the pushout bond strength of three calcium silicate sealers.
July 1, 2015ABSTRACT OBJECTIVE: To compare the effects of irrigation protocols on the push-out bond strength of calcium silicate materials at two different time periods (7-days and 3-months). MATERIALS AND METHODS: Root canals (n=300) were irrigated with one of the following (n=60): group 1 (3% NaOCl–17% EDTA); group 2 (17% EDTA–3% NaOCl); group 3 (1:1 mixture of […]...Read more
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Marginal Adaptation Evaluation of Biodentine and MTA Plus in “Open Sandwich” Class II Restorations
May 1, 2015Abstract Purposes: This study aimed at evaluation of two different commercially available calcium silicate materials (Biodentineand mineral trioxide aggregate [MTA] Plus) used as dentin substitute. Materials and Methods: Sixty Class II cavities were prepared in extracted mandibular third molars, with margins extending 1mm below the cementum–enamel junction.The samples were divided into three groups on the basis […]...Read more
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Ion Release, Porosity, Solubility, and Bioactivity of MTA Plus Tricalcium Silicate
October 1, 2014Abstract Introduction: The aim of this study was to evaluate MTA Plus (Prevest Denpro Limited, Jammu, India, for Avalon Biomed Inc) material’s properties, namely calcium release, the pH change, solubility, water sorption, porosity, surface morphology, and apatite-forming ability after immersion in simulated body fluid. i Methods: Two tricalcium silicate powders (MTA Plus and ProRoot MTA; Dentsply Tulsa Specialties, Tulsa, OK) and Dycal (Dentsply […]...Read more
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Capping a Pulpotomy with Calcium Aluminosilicate Cement: Comparison to Mineral Trioxide Aggregates
September 1, 2014Abstract Introduction: Calcium aluminate cements have shown little affinity for bacterial growth, low toxicity, and immunogenicity when used as a restoration material, but calcium aluminate cements have not been tested in vivo in pulpotomy procedures. Methods: To address this question, a calcium aluminosilicate cement (Quick-Set) was tested along with 2 mineral trioxide aggregates, ProRoot MTA […]...Read more
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Evaluation of Compressive Strength of Hydraulic Silicate-based Root-end Filling Materials
July 1, 2014Abstract Introduction: Hydraulic silicate cements such as mineral trioxide aggregate (MTA) have many clinical advantages. Newer hydraulic silicate materials have been developed that improve on the limitations of mineral trioxide aggregate such as the long setting time and difficult handling characteristics. The purpose of this study was to examine the effect of saline and fetal […]...Read more
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Push-out bond strength of MTA with antiwashout gel or resins
May 1, 2014Abstract Aim: Assessment of the push-out bond strength of four MTA-based formulations for use as root-end filling materials. Methodology: MTA Plus mixed with (i) water (‘MTA-W’); (ii) a proprietary water-based antiwashout gel (‘MTA-AW’); (iii) Superbond C&B chemically curing resin (‘MTA-Chem’); and (iv) Heliobond lightcuring resin (‘MTA-Light’) was tested. Root slices 3 mm thick human had […]...Read more
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X-ray diffraction analysis of MTA-Plus, MTA-Angelus and DiaRoot BioAggregate.
April 1, 2014ABSTRACT OBJECTIVE: The purpose of this study was to investigate and compare the crystalline structures of recently released MTA Plus (MTAP), MTA Angelus (MTA-A), DiaRoot BioAggregate (BA) by X-ray diffraction (XRD) analysis. MATERIALS AND METHODS: Phase analysis was carried out on powder and set forms of tested materials. The powder specimens placed into sample holders […]...Read more
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In Vitro Biocompatibility and Oxidative Stress Profiles of Different Hydraulic Calcium Silicate Cements
February 1, 2014Abstract Introduction: MTA Plus is a new calcium silicate cement with unknown cytotoxicity characteristics. The objectives of this study were to examine the effect of MTA Plus on the viability, apoptosis/necrosis profile, and oxidative stress levels of rat odontoblast-like cells. Methods: MDPC-23 cells were exposed to gray and white MTA Plus (GMTAP, WMTAP), gray and […]...Read more
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In Vitro Osteogenic/Dentinogenic Potential of an Experimental Calcium Aluminosilicate Cement
September 1, 2013Abstract Introduction: Calcium aluminosilicate cements are fast-setting, acid-resistant, bioactive cements that may be used as root-repair materials. This study examined the osteogenic/dentinogenic potential of an experimental calcium aluminosilicate cement (Quick-Set) by using a murine odontoblast-like cell model. Methods: Quick-Set and white ProRoot MTA (WMTA) were mixed with the proprietary gel or deionized water, allowed to […]...Read more
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The setting characteristics of MTA Plus in different environmental conditions
September 1, 2013Abstract Aim: Characterization and assessment of the hydration reaction of mineral trioxide aggregate (MTA) Plus exposed to different environmental conditions. Methodology: The specific surface area, surface morphology and characterization of un-hydrated MTA Plus (Avalon Biomed Inc. Bradenton, FL, USA) were investigated. The specific surface area was compared with that of ProRoot MTA (Dentsply International, Tulsa […]...Read more
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Retreatability of 2 Mineral Trioxide Aggregate-based Root Canal Sealers: A Cone-beam Computed Tomography Analysis
July 1, 2013ABSTRACT INTRODUCTION: The retreatability of recent calcium silicate or mineral trioxide aggregate (MTA) sealers has not yet been assessed. The aim of this study was to evaluate the removal of 2 MTA-based sealers (MTA Fillapex [Angelus Soluções Odontológicas, Londrina, PR, Brazil] and MTA Plus [Prevest-Denpro, Jammu City, India]) using a rotary retreatment system, considering an […]...Read more
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Mineral trioxide aggregate with anti-washout gel – Properties and microstructure
March 1, 2013Abstract Introduction:Calcium aluminosilicate cements are fast-setting, acid-resistant, bioactive cements that may be used as root-repair materials. This study examined the osteogenic/dentinogenic potential of an experimental calcium aluminosilicate cement (Quick-Set) by using a murine odontoblast-like cell model. Methods: Quick-Set and white ProRoot MTA (WMTA) were mixed with the proprietary gel or deionized water, allowed to set completely […]...Read more
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A quantitative method for determining the anti-washout characteristics of cement-based dental materials including mineral trioxide aggregate
February 1, 2013Abstract: Aim: To introduce and assess a novel method for measuring washout resistance of cement-based dental materials, including mineral trioxide aggregate (MTA), to qualitatively verify the results with a clinical simulation and to evaluate the washout resistance of a new root-end filling material. Methodology: A method for assessment of washout resistance of root-end filling materials was developed by adapting the CRD-C 661-06 […]...Read more
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Effects of an Experimental Calcium Aluminosilicate Cement on the Viability of Murine Odontoblast-like Cells
July 1, 2012Abstract Introduction: Quick-setting calcium aluminosilicate cement with improved washout resistance is a potential substitute for calcium silicate cements in endodontics. This study examined the effect of an experimental calcium aluminosilicate cement (Quick-Set; Primus Consulting, Bradenton, FL) on the viability of odontoblast-like cells. Methods: The biocompatibility of Quick-Set and white ProRoot MTA (WMTA; Dentsply Tulsa Dental […]...Read more
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Effects of Calcium Silicate-based Materials on Collagen Matrix Integrity of Mineralized Dentin
June 1, 2012Introduction: Calcium silicate–based materials (CSMs) are used in various endodontic procedures. The present study examined whether prolonged contact of mineralized dentin with recently commercialized versions of these materials adversely affects dentin collagen matrix integrity. Methods: Dentin slabs prepared from extracted human third molars (7 3 0.3 mm) were divided into 3 groups on […]...Read more
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Effects of Calcium Silicate–based Materials on the Flexural Properties of Dentin
May 1, 2012Introduction: Prolonged exposure of root dentin to calcium hydroxide alters the fracture resistance of dentin. Calcium silicate–based materials (CSMs) used in endodontics release calcium hydroxide on setting. This study examined whether prolonged contact of dentin with CSMs adversely affects its mechanical properties. (J Endod. 2012 May;38(5):680-3. ) ...Read more
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Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate
February 1, 2012Abstract: Fluoride-releasing restorative materials are available for remineralization of enamel and root caries. However, remineralization of dentin is more difficult than remineralization of enamel due to the paucity of apatite seed crystallites along the lesion surface for heterogeneous crystal growth. Extracellular matrix proteins play critical roles in controlling apatite nucleation/growth in collagenous tissues. This study […]...Read more
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Biocompatibility and Osteogenic Potential of New Generation Endodontic Materials Established by Using Primary Osteoblasts
August 1, 2011Abstract Introduction: Generex A and Generex B (calcium silicate based), Capasio (calcium-phospho-alumino silicate based) along with Ceramicrete-D (magnesium phosphate based) are being introduced as a new generation of endodontic materials with the potential to facilitate bone healing. The aim of this study was to evaluate the biocompatibility and osteogenic potential of these new materials by […]...Read more
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Physical and Chemical Properties of New-generation Endodontic Materials
March 10, 2010J Endod. 2010 March , 36(3):524-8. Porter ML, Berto A, Primus CM, Watanabe I. Abstract Introduction: Mineral trioxide aggregate (MTA), white and gray, has many uses in endodontic therapy but is limited by its difficult handling characteristics. This study compared the physical and chemical properties of white MTA (WMTA) with three experimental root-end filling materials: […]...Read more